Looking for the best supplements for Peyronie’s disease? if yes, then you have arrived at the right place because in this article we are going to review various supplements available for the treatment and management of Peyronie’s disease.
Current treatment approaches for Peyronie’s disease involve supplementation with Vitamin E, POTABA, Collagenase Clostridium injection (Xiaflex), Acetyl-L-carnitine, Colchicine, and Scar tissue dissolving enzymes.
In this article, we will review what are the best supplements for Peyronie’s disease and how effective they are.
But before we get into the breakdown of the best supplements for Peyronie’s disease we should have basic knowledge of what Peyronie’s is and how supplementation can help to recover from it.
What is Peyronie’s disease?
Peyronie’s disease (PD) is one of the most common problems of 21st-century men. it is characterized by excessive scar tissue formation which causes significant curvature.
It is a non-cancerous condition also known as wound healing disease which affects tunica albuginea. it is one of the most common men’s problems affecting 1 in 10 men in the United States.1Sandean DP, Lotfollahzadeh S. Peyronie Disease. [Updated 2022 Aug 29].
Mostly men aged above 57 – 60 are at high risk of it. however, there are noted cases where it affected boys of age 21 years old.
Do supplements work for Peyronie’s disease?
Peyronie’s disease is mainly caused due to excessive scar tissue formation on the penis. any supplement having benefits in the reduction of scar tissue will eventually work for the treatment of Peyronie’s disease.
Vitamin E is the biggest name in the supplement used in Peyronie’s disease. you can read here about its effectiveness.
What supplements are effective in Peyronie’s disease?
Although, there are no FDA-approved supplements available in the market. But, there are some supplements or natural ingredients has shown improvement in the reduction of scar tissue and penile curvature.
Tamoxifen, Vitamin E, Omega-3 fatty acids, Procarbazine, or a combination of Vitamin E with L-carnitine are the best supplements available for Peyronie’s disease.
Best Supplements for Peyronie’s disease
In the following article, we discuss and review the best supplements available in the market. you can directly buy it from the given links.
1. Scar tissue dissolution supplement
Scar tissue dissolution enzymes are the most effective type of supplement available to treat Peyronie’s disease.
Maximum strength Serrapeptase or Trebinase are the most effectively used enzyme supplement in the treatment of Peyronie’s disease.
Trebinase 320,000 FU’s Per Capsule Advanced Systemic Enzyme
Enzyme supplement for Peyronie’s disease
- Trebinase 320,000 FU’s Per Capsule is a blend of advanced systemic enzymes which effectively reduce scar tissue of Peyronie’s disease.
- Contains high-quality Serrapeptase, Nattokinase, Seaprose, Protease, Bromelain, Lipase, and Alma.
- Effectively dissolves Internal Scar Tissue/Fibrosis and prevents the formation of new scar.
- Cleanses your bloodstream and reduces unhealthy fibrin levels.
Pros
- Most effective enzyme for scar tissue dissolvement
- Normalize fibrin levels in the body
- Strongest and most effective
Cons
- Non-refundable product (not to worry as its effectiveness is already tested by us)
Dosage
For the first three days, it is recommended to single pill and then start to take at least three pills each day. you can take it in the morning, noon and evening for maximum benefits.
Take it 30 to 60 minutes before a meal or after 2 hours of a meal.
Final Words
Trebinase 320,000 FU’s Per Capsule Advanced Systemic Enzyme is the best-in-class scar-dissolving enzyme supplement with proven efficacy. you can increase its efficacy by using it with a Serrapeptase supplement.
Read – Shockwave Therapy for Peyronie’s Disease (Does it work?)
Serrasolv 360 Serrapeptase Supplements – dissolve plaque
Serrapeptase enzyme supplement for Peyronie’s disease
- Serrasolve 360 is the highest quality maximum strength 180,000 units of Serrapeptase. It effectively dissolves scar tissue and reduces pain and inflammation associated with Peyronie’s disease.
- The reason why we chose this product at the top spot of best supplements for Peyronie’s disease is that It’s a proven enzyme for the dissolution of excessive scar tissue.
- 2.5x Absorption – this product contains micro enteric-coated pills which are 2.5x more absorption.
- Each pill contains 180,000 su’s of the proteolytic enzyme from Serratia bacteria strain E15.
Pros
- Most effective and advanced scar tissue dissolvement supplement.
- Cost-effective formula.
- Ultra-high potency maximum strength Serrapeptase Pills.
- Enteric-coated pills are protected from stomach acid.
- Dissolve scar tissue, and reduce inflammation and pain with proteolytic enzymes.
Cons
- N/A
Recommended dosage
Take a single capsule three times a day for 30 to 40 minutes before a meal or after 45 minutes of a meal.
Final words
Serrasolv 360 Serrapeptase Supplements are the best supplements for Peyronie’s disease. you can use it with a Trebinase enzyme supplement for maximum effectiveness.
2. Vitamin E
It is one of the most researched supplements available in the market. it works by Inactivating free radicals in the body. it does it by reducing oxidative stress in the body.
for more effectiveness it should be used in the combination with a colchicine supplement.
A clinical trial conducted in the early stages of Peyronie’s disease has shown effectiveness in scar tissue reduction and improvement in penile curvature.2Prieto Castro RM, Leva Vallejo ME, Regueiro Lopez JC, Anglada Curado FJ, Alvarez Kindelan J, Requena Tapia MJ. Combined treatment with vitamin E and colchicine in the early stages of Peyronie’s disease.
Thorne Ultimate-E – 60 Gelcaps
Best vitamin e supplement for Peyronie’s disease
- The reason why it is the first choice of supplement for Peyronie’s disease is that it contains vitamin e from natural ingredients.
- It contains vitamin e from a natural source also known as mixed Tocopherols. The manufacturing process removes allergic soy while distillation.
- Free from gluten, it can be taken by people with peanut, soya, or eggs allergy.
- Also improves cardiovascular health.
Pros
- Cost-effective formula
- Can be taken with other nutritional supplements
- Single container lasts for 2 months
- Naturally sourced vitamin e
- Softgel capsule easy to swallow
- Gluten and dairy free
Cons
- N/A
Does it work?
Yes, Thorne Ultimate-E – Which contains All of The Natural Forms of Vitamin E does work for Peyronie’s disease. it has shown to be maximum effective if taken in the early stages.
Final Words
Thorne Ultimate-E – Contains All of The Natural Forms of Vitamin E and is the best supplement available for the management of Peyronie’s disease.
Read – What is Hourglass Peyronie’s Disease
Solgar Vitamin E 670 mg
Best vitamin e supplement for Peyronie’s disease
- If you are looking for an alternative vitamin e supplement for Peyronie’s disease you should go with Solgar Vitamin E 670 mg it is one of the most popular vitamin e supplements sold on amazon.
- This vitamin e supplement supports a natural reduction of scar tissue and effectively reduces the curvature of the penis.
- It contains Vitamin E (as d-Alpha Tocopherol) and d-Gamma, d-Delta, and d-Beta Tocopherols in soft gel capsules which provides rapid absorption.
- The product is Gluten, Wheat & Dairy Free so people with any known allergies don’t have to worry about its allergy.
Pros
- Best-selling vitamin e supplement
- Gluten, Wheat & Dairy free
- Natural source
- Maximum absorption
- Sugar, Salt & Starch free
Cons
- N/A
Final Words
Solgar Vitamin E 670 mg is another best-in-class vitamin e supplement for the management of Peyronie’s disease. if you are looking for a cost-effective vitamin e supplement then you should go with it without any hesitation.
3. Acetyl-L-carnitine
Acetyl-L-carnitine is another recommended supplement in the treatment of Peyronie’s disease.
L-carnitine is a naturally occurring amino acid produced in the brain, liver, and kidneys. it plays important role in many vital functions of the body.
According to one study, acetyl-L-carnitine has shown significant improvement in Peyronie’s disease if used for three months continuously.3Biagiotti G, Cavallini G. Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie’s disease: a preliminary report.
In a study conducted by BJU International, Acetyl-L-carnitine was shown more effective than Tamoxifen in treating the pain associated with PD and inhibiting disease progression effectively.4Biagiotti G, Cavallini G. Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie’s disease: a preliminary report. BJU Int. 2001
Nutricost L-Carnitine Tartrate 1,000mg, 240 Capsules
- Nutricost L-Carnitine Tartrate provides 1000mg of L-Carnitine Tartrate in a single serving (2 pills).
- Nutricost is a trusted brand for more than five decades. it ensures the highest quality of ingredients.
- Effectively reduces pain and penile curvature of Peyronie’s disease effectively.
- Third-party tested with gluten-free formula.
Pros
- Highest quality L-Carnitine formula.
- Trusted brand.
- Maximum strength formula.
- Complete dose for 2 months.
- Cost-effective formula.
Cons
- Swallowing capsules can be difficult for some consumers.
Recommended dosage
As a dietary supplement, take 2 capsules daily with 8-12 oz of water. or as advised by your doctor.
Final words
Nutricost L-Carnitine Tartrate 1,000mg, 240 Capsules is an overall good quality supplement for Peyronie’s disease but it is usually given in combination with a Vitamin e supplement.
Read – Do vacuum pumps work for Peyronie’s disease?
NOW Supplements, Acetyl-L Carnitine 500 mg
- NOW Supplements, Acetyl-L Carnitine 500 mg is another one of the top-rated best supplements for Peyronie’s disease.
- Acetyl-L-Carnitine (ALC) is energy production by assisting energy production by converting fat into ATP (cellular fuel).
- Now food has been a trusted brand for dietary supplements. you can trust this formulation for various health benefits.
Pros
- Trusted brand.
- Effective and highly pure ingredients.
- 2 months dosage.
- A family-owned business since 1968.
- No hidden ingredients.
Cons
- Monotherapy is not recommended.
- Taste or swallowing difficulties can be there.
Final words
NOW Supplements, Acetyl-L Carnitine 500 mg is another supplement for Peyronie’s disease. you should take it if you are looking for a cost-effective supplement that has high efficacy.
4. Omega -3- Fatty acids
Omega -3- Fatty acids are the most widely used supplements for various health benefits. its use in Peyronie’s disease has shown a positive effect on the improvement of Peyronie’s disease.
It works by Anti-inflammatory action which limits the effects of eicosanoids that is responsible for scar tissue sustainability.
Nordic Naturals Ultimate Omega, Lemon Flavor
- Nordic Naturals Ultimate Omega, Lemon Flavor another powerful supplement for Peyronie’s disease. it contains omega-3-fatty acid which acts directly on penile pain.
- It contains highly pure omega-3 fatty acids sourced from freshly caught wild fish.
- #1 fish oil brand in the USA, it provides many useful health benefits like improvement in brain function and heart health.
- High absorption formula with rapid action.
Pros
- #1 Fish oil brand in the USA.
- Sourced from natural wild fresh fish.
- No fishy aftertaste.
- High absorbtion formula.
- Comes in various flavors.
Cons
- N/A
Final words
Omega 3 fatty acids are a powerful source of antioxidant that prevents pain and inflammation associated with Peyronie’s disease. for additional effectiveness, you can use it with scar tissue-dissolving supplements.
Omega 3 Fish Oil – EPA & DHA Omega-3 Fatty Acids
- Omega 3 Fish Oil – EPA & DHA Omega-3 Fatty Acids is a revolutionary formula with advanced Triglyceride Natural State Technology which effectively reduce pain and inflammation of Peyronie’s disease.
- Each capsule contains 1000mg of omega-3 fatty acids having recommended ratio of 4:2.
- 400 mg of EPA, 200 mg of DHA, and 400 mg of other essential fatty acids.
- The suggested Dosage is one soft gel twice daily – which meets the daily recommended dose.
Pros
- 4:2 EPA-DHA ratio.
- Highly pure ingredients.
- Reduce depression associated with Peyronie’s disease.
- Cost-effective formula.
Cons
- Capsule size may be concerning.
Dosage recommendations
Omega 3 Fish Oil – EPA & DHA Omega-3 Fatty Acids are recommended to take a single pill once a day. with a glass of water usually after a meal.
5. Colchicine
Colchicine has been used off-label for the treatment of Peyronie’s disease it is usually effective in restricting the growth of scar tissue formation in Peyronie’s disease.
This effectively works in the PD due to its ability to depolymerize tubulin; inhibit cell mitosis, leukocyte adhesion, and collagen transport.5Sadiq NM, Robinson KJ, Terrell JM. Colchicine. [Updated 2022 Jun 5].
Commonly noted side effects of this herb are Nausea, diarrhea, abdominal pain, and aplastic anemia.
This study of 4.7 months of use of colchicine combined injection and stimulation test can provide a significant improvement in Peyronie’s disease.6Kadioglu A, Tefekli A, Köksal T, Usta M, Erol H. Treatment of Peyronie’s disease with oral colchicine: long-term results and predictive parameters of a successful outcome. Int J Impot Res. 2000 Jun;12(3):169-75.
Another study shows combined supplementation of Vitamin E and Colchicine in patients with less than 30° of curvature and no erectile dysfunction can be used to maintain Peyronie’s disease.7Combined treatment with vitamin E and colchicine in the early stages of Peyronie’s disease
Read – Xiaflex Before and After Peyronie’s Disease Treatment
6. Tamoxifen
Tamoxifen is an anticancer drug having been proven to reduce the risk of breast cancer in women’s.
Due to its property of restricting abnormal growth of any tissue including scar tissues it has potential use in the prevention of Peyronie’s disease.
According to a study published in the Korean Society for Sexual Medicine and Andrology, a combination of Tamoxifen and Colchicine has shown a significant decrease in pain and penile curvature if used in the early stages.8Park TY, Jeong HG, Park JJ, Chae JY, Kim JW, Oh MM, Park HS, Kim JJ, Moon DG. The Efficacy of Medical Treatment of Peyronie’s Disease: Potassium Para-Aminobenzoate Monotherapy vs. Combination Therapy with Tamoxifen, L-Carnitine, and Phosphodiesterase Type 5 Inhibitor. World J Men’s Health. 2016 Apr;34(1):40-46.
Another study was conducted on 36 patients of Peyronie’s disease, given 20mg of Tamoxifen for 3 months. Results showed improvement in 50 % of patients. it also shows shrinkage in the scar tissue.9Ralph DJ, Brooks MD, Bottazzo GF, Pryor JP. The treatment of Peyronie’s disease with tamoxifen. Br J Urol. 1992 Dec;70(6):648-51.
7. POTABA
POTABA is another widely known supplement used for various health benefits.
Potassium para-aminobenzoate A.K.A POTABA has long been widely used in the treatment of the plaque, curvature, and pain produced by chronic Peyronie’s disease.
POTABA is believed to work by Decreasing fibrosis and inhibiting collagen formation by decreasing serotonin levels, increasing monoamine oxidase activity, and inhibiting fibroblast glycosaminoglycan secretion.
A study published in the European Urology Journal suggested use of Potassium para-aminobenzoate for 12 months has demonstrated a protective effect on the worsening of penile curvature.10Potassium Paraaminobenzoate (POTABA™) in the Treatment of Peyronie’s Disease: A Prospective, Placebo-Controlled, Randomized Study
The most common side effects of Potaba are Acute hepatitis, hypoglycemia, GI distress, and rash.
